Risk of filing Job Ads before PWD is approved and getting medical reports even before I485 is current?

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For Green Cards, can we file the Job Ads before PWD is approved, some say it is not a good idea to file before but don't understand the reasoning? 

Can we get the medical reports ahead even before I485 is current so we are prepared ahead?

Why do some companies fail to get PERM approved. What are some important steps to consider in order to get them approved?

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